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One way to limit hair loss is a technique called scalp cooling, which involves the patient wearing headgear connected to a machine that runs a cooling liquid through it, to reduce blood flow to the hair follicles and therefore the amount of drug they can absorb. Their efficiency can vary, but intrials, about half of the patients who tried them retained 50% of their hair or more.
But scalp cooling has its drawbacks. “One is that the machines are large and physically anchored in place, which means patients are getting treated for hair loss before, during and after each chemo session, spending two or three times as long in the hospital as they would be otherwise,” said Aaron Hannon, CEO and founder of Luminate, an Irish startup that is working on a helmet that aims to improve on current scalp cooling technology.
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It uses pressure rather than cooling, which means it doesn’t need a pre-cooling period before treatment begins, meaning it works faster. It also aims to improve on another important factor, according to Hannon: “The comfort that patients experience during treatment,” he said. “Cooling therapy is very cold and somewhat painful for patients to go through, so there’s definitely been a lot of user feedback around trying to come up with a more comfortable alternative to the cooling devices.”
Luminate has been running trials in Europe with encouraging results: About 75% of patients did not have any hair loss, according to the company. “Patients on a very common regimen for breast cancer, for example, finished 12 cycles of treatment and kept almost all of their hair,” Hannon said. “We haven’t had any serious adverse events related to the device, so safety has been pretty good.”
Hair loss has a significant impact on patients, Hannon says, not just on their appearance but on their overall well-being and their ability to relate toother people. “One of the things that encouraged us to even start this whole venture was just the experiences of patients,” he said.
“I’ll never forget speaking to a young mom who had breast cancer, and she was telling us how hair loss wasn’t just important to her in the sense that we might think about, from an aesthetic point of view — she was saying that she just wanted her kids to think that she was OK and to not have to have the conversation with them that their mom was sick. But hair loss was the thing that forced that to happen.”
Luminate aims to start clinical trials in the US and Europe next year, with a goal of launching commercially in the US first, once the technology has been cleared by the US Food and Drug Administration. Commercial launch would immediately follow, with the device being offered to patients through health insurance companies. The cost to insurers is projected to be around $1,700 per helmet; in comparison,a course of scalp cooling treatment typically costsbetween$1,500 and $3,000.
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Luminate, which employs a team of 35, started in 2018 as a research project at the University of Galway, in Ireland, with Hannon working alongside co-founders Barbara Oliveira and Martin O’Halloran, who is director of the university’s Translational Medical Device Lab. It spun off in 2021 and has recently raised $15 million in series A funding.
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“Patients in the past may have struggled to agree to a certain treatment if they knew that they were going to lose their hair,” she said. “They may opt for something that’s not as optimal, knowing that hair loss was going to be a real possibility, or they may delay their care.”
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“For those patients we’ve been able to have success with, the impact has been massive,” he said. “For some, this has changed their whole experience of going through chemotherapy treatment, and that is really, really heartwarming.”
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