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Each human is a finely tuned orchestra of more than 37 trillion cells. Mapping this little-known world is one of biology’s greatest challenges — and one in which scientists say they just made a significant dent.

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“Cells are the basic unit of life, and when things go wrong, they go wrong with our cells first and foremost,” said Aviv Regev, founding cochair of the Human Cell Atlas and executive vice president for research and early development at Genentech, a biotechnology company based in South San Francisco, California.

“The challenge we’ve had is that we didn’t know the cells well enough to understand how variants and mutations in our genes are really affecting disease. Once we have this map, we’re able to better find the causes of disease,” she said at a news briefing Tuesday.

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“Now, years later, the resolution of the map is a lot higher,” she said. “It’s more like Google Maps, where you have a very high-resolution view of the real topography, and then on top of that, you have the street view that really explains to you what is going on there. And on top of that, you can even see the driving patterns, like the dynamic changes that happen during the day,” she added.

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It was once thought there were only 200 or so different types of cells. Scientists now know there are thousands.

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“This is just an incredibly exciting journey, in terms of our voyage through the human body and discovery of fundamental new insights into our cells,” said Sarah Teichmann, founding cochair of the Human Cell Atlas and a professor at the Cambridge Stem Cell Institute at the UK’s University of Cambridge.

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English scientist Robert Hooke discovered cells in 1665, looking at cork under a microscope. He introduced the word cell because the patterns made by the cellulose walls of dead cork reminded him of blocks of cells used by monks. However, it was 200 years later when scientists finally understood that cells werethe fundamental unitof the human body.

Unlike theoriginal draft human genome, which was predominantly based on a single individual, the cell atlas aims to be globally representative and involves researchers and human tissue samples from around the world.

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During the Covid-19 pandemic, the Human Cell Atlas community used the available data to reveal that the nose, eyes and mouth were most vulnerable to infection.

“It was only clear through the Human Cell Atlas data that those cells were … entry points before the virus continued into the internal organs. That really illustrates quite simply how important a healthy reference map of the human body is, and a deep molecular understanding of ourselves,” Teichmann said.

Jeremy Farrar, chief scientist at World Health Organization, who was not involved in the research, agreed that insights emerging from the atlas are “already reshaping our understanding of health and disease.”

“This landmark collection of papers from the international Human Cell Atlas community underscores the tremendous progress toward mapping every single kind of human cell and how they change as we grow up and age,” Farrar said in a statement.

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