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“Who doesn’t want to see a dodo? Good God, I do. A mammoth. I mean, wow, amazing,” said Melanie Challenger, the deputy co-chair of the Nuffield Council on Bioethics in the United Kingdom.
Challenger, who is the author of “How To Be Animal: A New History of What it Means To Be Human,” argues that de-extinction is a fundamentally misleading term. “It’s not de-extinction, it’s genetically engineering a novel organism to fulfill the functions, theoretically, of an extant (living) organism. You’re not bringing anything back from the dead,” she said. “And all the way through the process, there are different, quite gnarly ethical considerations.”
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From this resurrection tool kit, cloning has the capability to create an animal that’s almost genetically identical.Dolly the Sheepbecame the first cloned mammal almost 30 years ago, and recently scientists successfully cloned theendangered black-footed ferret. But the process has beenhit-and-miss, and it’s unlikely to be useful in attempts to revive animals that disappeared a long time ago.
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High-profile investors in the endeavor include “Lord of the Rings” director Peter Jackson, socialite Paris Hilton, former professional football player Tom Brady and professional golfer Tiger Woods; as well as investment firms such as Breyer Capital. The latest infusion of cash comes from TWG Global, the investment vehicle of Mark Walter, controlling owner of the Los Angeles Dodgers baseball team and a co-owner of Chelsea Football Club in the UK.
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For the Tasmanian tiger or thylacine, Lamm said the pace of progress has been quicker than expected. Colossal scientists have been able to make 300 genetic edits into a cell line of a fat-tailed dunnart, which is the marsupial that Colossal has chosen as its base species and future surrogate. The company has sequenced what Lamm described as the highest-quality ancient genome to date for any animal.
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However, many of the developments have not been published in scientific journals, meaning they can’t be scrutinized by other scientists as is typical during the peer-review process and won’t become publicly available for the benefit of the research community.
Lamm said Colossal’s mission as a business is not to publish scientific papers, which is a monthslong, if not yearslong, process. However, he said thata paper on the creation of elephant iPSCs is in peer review. The company’s academic partners are planning to submit their work to journals, including the thylacine genome, in time, he added.
Colossal has recruited respected high-profile scientists, and many other experts act in advisory roles, including some initially skeptical of some of the company’s goals. They include molecular paleobiologist Beth Shapiro, Colossal’s chief science officer, who is currently on a leave of absence from her role as professor of ecology and evolutionary biology at the University of California Santa Cruz.
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“To be clear getting something that is 100% identical behaviorally, physiologically, genetically to a mammoth isn’t possible,” she told 【 - Free Stock Selection with 300% Return 】 in October. “Once a species is lost, it’s gone, and we need to be investing in making sure that things don’t become extinct.”
Colossal is increasingly using its deep pockets to fund conservation efforts including work to save the world’smost endangered rhino species: the northern white rhino. The company is also collaborating on the development ofa vaccine for a herpes-like diseasethat can kill elephants. And Colossal has entered into a partnership withthe conservation organization Re:wildto use biotechnology in its projects.
Colossal’s stated end goal for its mammoth project is a world where the elephant-mammoth hybrids lumber through the Arctic permafrost compressing the snow and grass that insulates the ground, slowing down permafrost thaw and the release of carbon contained in this fragile ecosystem.
It’s “absurd” to imagine herds of cold-adapted elephants making a significant impact on a region that’s warming faster than anywhere else in the world in the time frame necessary to make a difference in the climate crisis, said Christopher Preston, a professor of environmental philosophy at the University of Montana.
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However, Clare Palmer, a professor of philosophy at Texas A&M University who specializes in animal and environmental ethics, noted that ecosystems are changing rapidly. She said bringing back animals may not work if the landscape is no longer the same.
“We also don’t have good knowledge of the welfare needs of members of extinct species and the offspring, for instance, would not be taught by their parents how to hunt, or forage, or relate to other species members,” Palmer said.
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