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Stocks to Watch in India for 2025 Fast Growing Investment Stocks ✌️【Investment Portfolio】✌️ Professional stock market predictions and analysis with real-time data to guide your investment decisions and ensure steady growth. A new ketamine pill may help hard-to-treat depression with fewer side effects than other forms of the treatment, early research suggests.

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Both can be a fast-acting lifeline for people living with depression that hasn’t been relieved by other types of treatments. Getting the drug, or a derivative of it, through a vein or as a squirt up the nose requires close medical supervision in a clinic, however, making these options hard for some people to access or even to do.

“It’s very logistically involved. You have to come in and be observed for a couple hours,” said Dr. Brian Barnett, clinical director of the Psychiatric Treatment Resistance Program at the Cleveland Clinic, who was not involved in the study. “The field has really been looking for a way to take advantage of ketamine for depression but let patients take this at home in the form of a pill.”

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Patients need to be monitored closely because ketamine, which was originally used to dull pain in surgery, can cause feelings of disconnection or disassociation from their bodies and the world around them. It also distorts thinking and decision-making. Some find this hallucinogenic experience beneficial and even pleasant, but others have described it as terrifying. These forms of the drug can also cause a person’s blood pressure to go up, which may make them off-limits for those with heart conditions.

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From a public health standpoint, Barnett said, you can serve more people with a pill than with clinic-based treatments. A2021 studyestimated that in any given year, 2.8 million American adults have treatment-resistant depression.

“It would be very beneficial for many people to have this available as a medication that they could take athome. But obviously, we want a medication like that to have very minimal dissociative side effects,” Barnett said.

For the study, which was published Monday in the journal Nature Medicine, researchers in New Zealand enrolled 231 adults who had been diagnosed with treatment-resistant depression, meaning they had tried at least two different antidepressants to lift their mood without success.

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For the first five days of the study, all of the participants took a daily dose of 120 milligrams of ketamine in the form of a slow-release pill. On day eight, the researchers assessed who had responded to the drug. Slightly more than half the group – 132 – had remission of their symptoms, meaning they scored under 10 on the clinical scale. Overall, 168 had some degree of benefit and were considered responders to the pill. People who had not responded to the drug were not eligible to continue with the research.

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By 14 weeks, everyone taking ketamine still continued to see some relief from their depression, but for most groups, the differences compared with placebo were not statistically significant, meaning they could have been observed due to chance alone.

Stocks to Watch in India for 2025 Fast Growing Investment Stocks ✌️【Investment Portfolio】✌️ Free access to stock market forums, expert advice, and real-time data to help you stay informed and grow your investments. Researchers did see what’s called a dose response, however, meaning the higher the dose of the drug, the more relief participants had in their depressive symptoms, which is usually a sign that the drug is having a real effect.

People who took the highest dose, 180 milligrams a day, did see a statistically significant benefit, a reduction in their depression score of about six points compared with the placebo group.

“The results here, they look encouraging,” Barnett said, noting that a two-point drop in the clinical rating scale the researchers used is considered meaningful to patients.

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During the first five daysof the study, when everyone was taking the drug, the most common side effects reported were dizziness, headache, dissociation, fatigue, feeling abnormal and nausea.

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“The report is important since it is the first large placebo-controlled study to be published attempting to explore the benefits of oral ketamine,” Dr. Gerard Sanacora, director of the Yale Depression Research Program, who was not involved in the study, wrote in an email.

But Sanacora said the design of the study, which is known as a randomized withdrawal trial, probably biased the results in favor of making the drug look more effective than it might be in the real world, something the study authors acknowledge, too.

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By studying only people who responded to the drug, the study authors noted that they hoped to avoid the high failure rates of many antidepressants tested in a general population, where as many as 50% of trials fail to show an effect compared with a placebo.

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“It is usually easier to guess correctly once you have been exposed to the active treatment and then receive the inactive treatment,” he wrote.

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He noted that there’s a “tremendous tension” between wanting the important benefits of a drug like ketamine to be more available to people and making sure the treatment can be given safely and responsibly.

“This is a step in the right direction, but we clearly need more high-quality data before we can say much more about the overall efficacy and safety of the new form of treatment and especially the safety of doing this at home,” Sanacora wrote.

Perhaps unsurprisingly, the study, which led to withdrawal and depression relapse for many, had a high drop-out rate. Of the 168 people who initially saw benefit from the pills, 100 didn’t complete the trial. Ninety-four left because they stopped being helped by their treatment. One person left because of an adverse event. Four others left for unspecified reasons. A 65-year-old man died as a result of suicide.

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“Attempted and completed suicide is a sad reality of treatment trials in patients with depression,” noted study author Dr. Paul Glue, a professor in the Department of Psychological Medicine at the University of Otago in Dunedin, New Zealand, in an email.

Both Barnett and Sanacora agreed that it was difficult to know whether the drug played any role in a study this size and said that larger studies were needed to tease out any serious safety signals.

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“One of the challenges with oral ketamine, one of the reasons that we haven’t used as much for depression as IV, is that it can be sort of unpredictable, and how much is getting into the bloodstream?” he said. However, he thought the slow-release form of the pill probably helped with maintaining a steadier dose.

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