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In 2018, Kiki Roark wrote in their family’s group text that she had been diagnosed with stage I breast cancer – the same disease that had taken their aunt’s life just a few years prior.

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Cancer rates have generally declined among men in the US early this century before leveling out, yet they appear to be climbing among women – especially young women. Cancer diagnoses are shifting from older to younger adults and from men to women, according toa report released Thursday by theAmerican Cancer Society.

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“Breast and thyroid cancer account for almost half of all cancer diagnoses in women younger than 50,” said Rebecca Siegel, lead author of the report and senior scientific director of surveillance research at the American Cancer Society.

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“Just because I was younger, I feel like they didn’t take me seriously,” Kiki said. “But I kept pushing the issue, saying, ‘No, something’s not right.’”

It took months, Kiki said, but she eventually got a mammogram. It showed signs of cancer, and a biopsy confirmed the diagnosis.

For treatment, she had both breasts removed in a double mastectomy and received the hormone therapy drug tamoxifen.

Charmella stayed by her sister’s side throughout the illness. And in the years after, Charmella said, she was inspired to stay on top of her routine breast cancer screenings by getting mammograms.

In the summer of 2022, one of those mammograms revealed that Charmella, a high school teacher and mother of two, had stage I breast cancer. She was 44 at the time.

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Charmella and Kiki had found themselves among the estimated1 in 3 women in the USwho will be diagnosed with cancer at some point in their lifetime.

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“We see for the first time, if you’re a woman under the age of 65, you’re now more likely to develop cancer than men in that same age group,” said Dr. William Dahut, chief scientific officer for the American Cancer Society.

“The other thing is, we’re seeing a change in – at the time of cancer diagnosis – the age of which patients develop cancer,” Dahut said.

“Age remains the number-one greatest risk factor for cancer overall, and that hasn’t changed. But we’re seeing some shifting,” he said. For men and women combined, “the only age group where we’re seeing actually an increase in cancer risk, in incidence going up, is under the age of 50.”

Charmella, now 47, and Kiki, 44, are cancer-free and doing well, but they know that as Black women in the United States, they are part of acommunityfacing significant disparities in cancer outcomes.

Even though Black women in the US have about a4% lower incidence rate of breast cancerthan White women, they are41% more likely to diefrom the disease, previous data from the American Cancer Society showed.

“You’re more likely to develop breast cancer as a White woman. You’re more likely to die of it as a Black woman, particularly when you look at the younger populations, where disparity numbers are greatest,” Dahut said.

Black people have a death rate that’s twice as high as White people’s for prostate, stomach and uterine corpus cancers, according to the report. Similarly, death rates for kidney, liver, stomach and cervical cancers among Native Americans are two to three times those seen in White people.

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Overall cancer survival rates are increasing, and the United States’ cancer mortality rate has continued to fall, averting nearly 4.5 million deaths from 1991 through 2022 – resulting in an overall drop of 34%, the new report said.

“Year after year, we observe a continued decline in cancer-related mortality, and that is very important,” said Dr. Mariana Chavez-MacGregor, a professor at The University of Texas MD Anderson Cancer Center in Houston, who was not involved in the new report.

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“I had a breast specialist, a [gynecologist] and a family doctor tell me it was nothing,” she said. “If I would have listened to them, we don’t know where I would be right now.”

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“In my professional opinion, this phenomenon is multifactorial. We cannot point at one specific factor, but it’s possible that changes in fertility patterns play a role,” Chavez-MacGregor said, referring to how pregnancy and breastfeeding have been associated with areduced risk of breast cancerlater in life.

“Obesity and alcohol consumption are likely contributing factors, as is a potential lack of physical activity,” she said. “Other unknown variables may also be at play,” such as environmental risk factors.

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“There is, and there needs to be, a greater shift in scientific research and the resources that are available for the scientific community to better understand how we can be more effective at preventing cancer, or at least reducing the risk of cancer,” Iyengar said.

“We certainly need to understand individual biology and how we can prevent cancer based on individual biology. But we need to expand that to understand a person’s lifestyle, their environmental risks,” he said. “The exposures and the risks of a younger person are likely very different than a traditional older person who’s at risk for cancer.”

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“We have to be prepared to support our younger men and women who are undergoing perhaps more aggressive cancer therapies while still dealing with young families and working in careers,” he said. “That ranges from practical considerations – like how we schedule chemotherapy treatments, for example, in a way that needs to be less disruptive to people’s lives and careers and families – to the types of treatments that we’re using.”

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