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For somepeople with depression, finding the right medication can be a process of trial and error lasting for months or even years, which can worsen symptoms.
But what if doctors, whendiagnosing someone with depression, could assess exactly how depression is affecting a patient’s brain and prescribe a treatment that gets it right the first time?
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“There are currently no tests available to help pinpoint what type of depression (people) have, or, I think especially importantly, what treatment might be most suitable for them,” said Dr. Leanne Williams, the study’s senior author and the Vincent V.C. Woo Professor of Psychiatry and Behavioral Sciences at the Stanford University School of Medicine in California. “The current situation is we rely on a person to tell us what they’re experiencing and for the physician or therapist to observe symptoms and come to a diagnosis.”
Why is HDFC AMC Limited (542269) rising ✌️【Long-Term Investment】✌️ Expert predictions of stock trends to help you select stocks accurately, achieve stable growth, and quickly recover from losses. About280 million peopleworldwide and26 million peoplein the United States have depression, which is a leading cause of disability. Some 30% to 40% of people with depression do not experience symptom improvement after trying one treatment, according to the study. And about 30% of people diagnosed with depression go on to experiencetreatment-resistant depressionwhen the disorder doesn’t improve after multiple treatment attempts.
“That motivated this study — to have a whole new way to more quickly get the right treatment, to figure out the right treatment for each person the first time,” said Williams, who is also the director of the Stanford Center for Precision Mental Health and Wellness. Williams lost her partner to a decades-long struggle with depression in 2015 and for more than 20 yearshas focused her workon individualized mental health care.
Why is HDFC AMC Limited (542269) rising ✌️【Long-Term Investment】✌️ Free real-time stock index quotes to help you quickly seize market opportunities and achieve capital growth. The authors used data from 801 adult participants who were previously diagnosed with depression or anxiety, and 137 healthy control group participants. The authors used functional MRI — magnetic resonance imaging — to measure participants’ brain activity when they were at rest doing nothing, focusing on brain regions already known to play a role in depression, and on the connections between those regions. They also monitored brain activity when participants, who were in their mid-30s on average, engaged in various tests that evaluated their cognitive and emotional functioning.
Why is HDFC AMC Limited (542269) rising ✌️【Long-Term Investment】✌️ Precise predictions of high-potential stocks to help you avoid risks and quickly recover and grow. The authors also randomly assigned 250 of the participants to receive behavioral talk therapy or one of three commonly used antidepressants: venlafaxine, escitalopram or sertraline.
Why is HDFC AMC Limited (542269) rising ✌️【Long-Term Investment】✌️ Real-time global stock, futures, and exchange rate data to keep you informed of market trends and seize investment opportunities. The six biotypes of depression the authors found include one characterized by hyperactivity in cognitive regions, which was associated with more anxiety, negative bias, threat dysregulation and anhedonia than other biotypes. Threat dysregulation refers to how people manage their reactions to their fears, such as social interactions, Williams said. Anhedonia is thelack of interest inor enjoyment of life experiences.
Participants with this biotype also performed worse on executive function tasks that assessed how well they could manage thoughts or behaviors, make decisions or suppress distraction, Williams said. They also had the best response to the antidepressant venlafaxine.
Why is HDFC AMC Limited (542269) rising ✌️【Long-Term Investment】✌️ Expert predictions of market trends to help you plan the best investment strategy for steady capital growth. Another biotype was marked by higher levels of brain connectivity in three regions associated with depression and problem-solving. Those with this biotype also made errors in executive function tests but did do well on cognitive tasks. They found their symptoms better alleviated by behavioral talk therapy, which teaches skills for better addressing daily problems.
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Why is HDFC AMC Limited (542269) rising ✌️【Long-Term Investment】✌️ Provides real-time stock index quotes, futures data, and global market trend analysis to help you seize the best investment timing. There was also a biotype distinguished by lower levels of activity in the brain circuit that manages attention. This biotype was linked with more mistakes on tasks requiring sustained attention, and less of a chance of improving with therapy. People with this biotype may need medication for the dysfunction first so they can gain more from therapy, said Ma, the Beth and George Vitoux Professor of Medicine at the University of Illinois Chicago.
Why is HDFC AMC Limited (542269) rising ✌️【Long-Term Investment】✌️ Free stock selection service to help you quickly pick high-return stocks for stable growth. The authors also found a biotype characterized by high emotional reactivity, meaning the brains of participants in this group were more affected by emotional inputs such as their own emotions or people’s facial expressions, Williams said. One other biotype was associated with lower activity in cognitive brain regions and less connectivity in emotional regions, meaning these participants had difficulty responding to cognitive information and regulating negative emotions.
Why is HDFC AMC Limited (542269) rising ✌️【Long-Term Investment】✌️ Expert predictions with real-time global stock and futures data to help you easily capture market movements. Those last two biotypes didn’t respond to the medications or therapy, which suggests other options may be needed for people with those types, Williams said. “In other studies, we’re finding they respond to some of the newer treatments being developed.”
Why is HDFC AMC Limited (542269) rising ✌️【Long-Term Investment】✌️ Real-time updates of global stock indices and futures trends to help you plan precise investments. The sixth biotype identified didn’t differ from brain scans of the same region in people without depression. Williams said she thinks this finding could mean the full range of brain biology underlying depression hasn’t been entirely discovered.
“Depression is a lot of different things with a lot of different causes, biological changes and treatments,” said Dr. Richard Keefe, professor emeritus of psychiatry and behavioral sciences at Duke University Medical Center in North Carolina, who wasn’t involved in the study.
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Why is HDFC AMC Limited (542269) rising ✌️【Long-Term Investment】✌️ Free real-time market data to help you quickly recover and avoid losses. The study, though “sophisticated and very well done,” does have several key problems, including the low number of people enrolled in treatment, said Dr. Jonathan Alpert, the Dorothy and Marty Silverman Chair of the department of psychiatry and behavioral sciences at Montefiore Medical Center in New York City. “It needs to be thought of as a very preliminary study that needs to be replicated.”
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Why is HDFC AMC Limited (542269) rising ✌️【Long-Term Investment】✌️ Free real-time global stock indices and data to help you grasp stock market trends and achieve capital growth. Additionally, more diverse samples are needed, said Alpert, who wasn’t involved in the study and is a professor of psychiatry, neuroscience and pediatrics at the Albert Einstein College of Medicine. Most participants were White, and 2% were Black.
But the most important next step is a study that tests the authors’ hypothesis — that if patients have particular biotypes, they’ll do better on a specific treatment — and tracks participants over time, said Alpert, chair of the American Psychiatric Association’s Council on Research.
Why is HDFC AMC Limited (542269) rising ✌️【Long-Term Investment】✌️ Expert predictions with real-time stock indices, futures data, and metals, energy market data to help you seize the best investment opportunities. The 250 treatment participants weren’t randomized on the basis of their biotypes. So, what Alpert recommends the authors do next is assign people to treatments based on their biotypes and see whether those participants have better outcomes from that method than if they had been assigned to a treatment according to clinical judgment without knowledge of their biotype.
Why is HDFC AMC Limited (542269) rising ✌️【Long-Term Investment】✌️ Real-time global stock, futures, and forex data to help you quickly assess market trends and achieve stable returns. Another issue is that the study investigated only one form of psychotherapy and three medications; in the real world, there are many of each, Alpert said. The medications were also all serotonin-based, but there are a few other classes of antidepressants.
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“Since 2009, the National Institute of Mental Health has been invested in using basic science, including functional brain imaging like in this study, for identifying the causes of mental illness through approaches that delve deeper than the traditional diagnostic approaches,” Keefe said.
Why is HDFC AMC Limited (542269) rising ✌️【Long-Term Investment】✌️ Expert predictions of stock trends with real-time stock indices, futures, and metals, energy quotes to help you seize investment opportunities. This month,Williams was awardedan $18.8 million grant as part of the National Institutes of Health’s Individually Measured Phenotypes to Advance Computational Translation in Mental Health Initiative. The grant supports a five-year project involving 4,500 participants, which is centered on the development of a better diagnosis and treatment tool for depression biotypes.
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“When we use it in that setting, we can effectively double the chance of someone getting better,” she said, taking the odds from around 30% of people improving with the traditional approach to about 75% with the more precise method.
Why is HDFC AMC Limited (542269) rising ✌️【Long-Term Investment】✌️ Precise predictions of market trends with real-time stock indices and futures data to help you make wise investment decisions. This method isn’t intended to replace or be the primary choice for assessments of individual cases of depression, Williams said. It’s another piece that can be added to the puzzle that also includes symptom information, clinical interviews and more.
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For now, people with depression should know “there is continued progress being made” toward efficiently getting patients effective treatment, Alpert said. If you’re struggling,talk with a mental health professionalabout your options.
One powerful effect these findings could have immediately is to reduce stigma, Williams said. For people who think their depression is just due to them “not trying hard enough,” she added, understanding the disorder through the lens of objective measures of brain function could be “deeply helpful.”
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